Tadalafil appeared on the market in the early 2000s, a few years after the famous “Viagra.” The first erectile dysfunction drug—sildenafil—became a historic breakthrough, but it had limitations: more frequent side effects, interaction with food, and a relatively short duration of action. That was when tadalafil emerged, offering a major advantage—a long duration of action of up to 36 hours.
| Trade name | Cialis (tadalafil) |
| Indications | Erectile dysfunction |
| Form | Tablets |
| Available dosages | 2.5 mg, 5 mg, 10 mg, 20 mg, and 40 mg |
| Onset of action | About 1 hour |
| Duration of effects | Up to 36 hours |
| Average price per tablet |
• 20 mg tablet: about $2.15 – $10.80 • 5 mg tablet: about $1.10 – $3.25 |
| Where to buy Cialis | BUY CIALIS ONLINE |
When a man becomes sexually aroused, the body releases nitric oxide, which relaxes the blood vessels of the penis and allows blood to flow into the cavernous bodies. There is an enzyme called PDE5 that interrupts this process. Tadalafil inhibits PDE5, allowing the erection mechanism to work longer and providing sufficient rigidity for sexual intercourse.
In addition to its effect on erection, tadalafil has a vasodilating effect and can improve blood circulation. It can also relieve lower urinary tract symptoms associated with the prostate, which often trouble older men.
The dose of tadalafil for sexual activity, to achieve a good erection and eliminate erectile dysfunction, ranges from 5 to 20 mg.
Twenty milligrams is the maximum single dose of tadalafil for sexual intercourse.
A dose of 5 mg is considered a therapeutic, maintenance dose and is prescribed as part of combination therapy for prostatitis, prostate adenoma, and other urological conditions. In complex therapy, the 5 mg dose is most commonly used.
Tadalafil is also available in 10 mg and 20 mg dosages, and generic Cialis is also available in a 40 mg dosage.
Tadalafil does not work immediately. Its peak effect occurs 2–3 hours after intake, and the effect lasts up to 36 hours. Therefore, it should not be taken immediately before sexual intercourse. The optimal timing is 1.5–2 hours before intimacy.
Studies have shown that combining tadalafil with light physical activity, such as walking, enhances its effect by up to 40%. If you simply take a pill and lie on the couch, the result will be worse than if you slightly “stimulate” blood circulation.
Another important point: tadalafil should not be taken on a completely empty stomach or immediately after eating fatty food, as fat slows down the absorption of the drug into the bloodstream.
If blood vessels have poor patency and are clogged with plaques and cholesterol, blood flow to the penis worsens and the effect of the drug decreases. Reduce excessive fatty food intake and increase physical activity. To improve microcirculation, add foods rich in omega-3 fatty acids, vitamin D3, and arginine to your diet. The better the condition of the blood vessels, the stronger and more stable the effect of tadalafil.
Alcohol and tadalafil are a poor combination. Even small amounts of alcohol lower blood pressure and weaken the effect of the drug. If you want to achieve maximum effect, avoid alcohol for at least 24 hours before taking tadalafil.
Tadalafil is prescribed by a doctor according to two regimens. The first is on demand: 20 mg taken 1–1.5 hours before the expected sexual intercourse. The second is daily use at a low dose of 5 mg. Any regimen is prescribed only after examining the patient. Do not self-medicate and do not switch from one regimen to another without consulting a doctor.
Tadalafil works through a vascular mechanism, but if testosterone levels are low, its effect will be incomplete. If a man experiences chronic fatigue, decreased libido, or weight gain, testosterone levels should definitely be checked. This does not mean taking tests before every sexual intercourse—it is simply important to monitor hormonal balance and correct it if necessary under the supervision of an andrologist. Otherwise, no stimulant will work at 100%.
No medication is completely free of side effects. The most common are:
• headache;
• facial flushing;
• nasal congestion;
• pain in the lower back or legs.
These symptoms often decrease over time. As for blood pressure, it usually may decrease slightly, and the main risk is combination with nitrates. Therefore, before starting treatment, it is important to discuss any concomitant medications and heart conditions with a doctor.